Pharmax HLC Child Plus Multi 30 Tablets

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$46.40
sub Category:
Children's Formulas
MPN:
PB24-30U
Type of delivery:
Chewable
Ingredient 1:
Bifidobacterium lactis
Ingredient 2:
Bifidobacterium bifidum
Ingredient 3:
Lactobacillus Acidophilus

Product Overview

Pharmax HLC Child Plus Multi- 30 Tablets

• Moderate level probiotic
• 12.5 billion CFU per dose
• Includes multivitamins
• Unique manufacturing process
• Utilized to help maintain high potency probiotic stability in combination with multivitamins
• Ambient-safe
• Manufactured to allow for ambient temperature (59-86°F) storage and 2 year shelf-life without compromising product stability and still meet or exceed label claims. While refrigeration will extend the shelf-life of probiotics, ambient-safe HLC Child + Multi provides a choice for practitioners who are concerned about product viability but do not have refrigeration facilities
• Natural blackcurrant flavor increases compliance

HLC Child + Multi probiotic formula provides two strains of Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis, essential to the maintenance of the child’s healthy gut flora. HLC Child + Multi provides an easy and enjoyable way for children to obtain daily multivitamins to support overall health (1)

Additional product info:
Nowadays, the increased use of anti-microbial medication, the consumption of sterile food and reduced family size that result in lower rates of infection during childhood also reduce early contact to microbes. Consequentially, the present increase in allergic diseases seen in the industrialized countries has been attributed, among several other phenomena, to a relative lack of microbial stimulation of the infantile gut immune system and the exaggerated hygiene of the typical western lifestyle during early childhood (2). Probiotics and prebiotics, alone or together (synbiotics), can influence the intestinal microbiota and modulate the immune response (3). Moreover, probiotics increase anti-inflammatory cytokines and gut impermeability to bacteria and toxins, and suppress pathogens (4). Most success has been obtained in primary prevention of atopic eczema. A limited number of studies also provided evidence for a beneficial effect of Bifidobacterium bifidum BGN4, B. lactis AD011, and Lactobacillus acidophilus AD031 in the management of allergic diseases (atopic eczema, allergic rhinitis) (5),(6).
T cell priming, as determined by allergen-induced proliferative responses, is believed to occur principally in early childhood in both atopic and non-atopic infants under the influence of multiple factors including environmental allergen exposure. It is considered that T cell priming with expansion of Th2 cells is a crucial factor in the development of atopic disease (7).

HLC Child + Multi is a moderate- level, long-term probiotics maintenance formula with added vitamins. Bifidobacterium bifidum and Lactobacillus lactis are found more commonly in the composition of the intestinal flora of non-allergic children , . In addition, HLC Child + Multi is indicated for dysbiosis , and symptoms associated with irritable bowel syndrome (IBS) which has also been shown in human double-blind, placebo-controlled clinical studies, at a core consortium of 25 billion CFU to:

• Reduce the risk of Clostridium difficile associated diarrhea in hospitalized patients
• Significantly improved the Symptom Severity Score of patients suffering from irritable bowel syndrome (IBS) and scores for quality of life, days with pain and satisfaction with bowel habit compared to placebo, when taken for 8 weeks.
• Indicated for allergies2,6, atopic dermatitis5,12, and dysbiosis6 which has also been shown in human double-blind, placebo-controlled clinical studies, at a core consortium of 25 billion CFU, to:
• Reduce the risk of Clostridium difficile diarrhea in hospitalized patients1, as well as reducing those who tested positive for the toxin while on antibiotics, regardless of whether they suffered from diarrhea or not7,8.
• Vitamins are added to support general health, help maintain immune function and to provide antioxidants for the maintenance of good health9.

References:
1 NHPD Monograph on multivitamins and minerals. 2007.
2 Ozdemir O. Various effects of different probiotic strains in allergic disorders: an update from laboratory and clinical data. Clin Exp Immunol. 2010 Jun;160(3):295-304.
3 Gourbeyre P, Denery S, Bodinier M. Probiotics, prebiotics, and synbiotics: impact on the gut immune system and allergic reactions. J Leukoc Biol. 2011 May;89(5):685-95.
4 Tarnow-Mordi WO, Wilkinson D, Trivedi A, Brok J. Probiotics reduce all-cause mortality and necrotizing enterocolitis: it is time to change practice. Pediatrics. 2010 May;125(5):1068-70.
5 Ozdemir O. Various effects of different probiotic strains in allergic disorders: an update from laboratory and clinical data. Clin Exp Immunol. 2010 Jun;160(3):295-304.
6 Kim JY, Kwon JH, Ahn SH, Lee SI, Han YS, Choi YO, Lee SY, Ahn KM, Ji GE. Effect of probiotic mix (Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double-blind, randomized, placebo-controlled trial. Pediatr Allergy Immunol. 2010 Mar;21(2 Pt 2):e386-93. e386
7 Smart JM, Suphioglu C, Kemp AS. Age-related T cell responses to allergens in childhood. Clin Exp Allergy. 2003 Mar;33(3):317-24.
11 Ozdemir O. Various effects of different probiotic strains in allergic disorders: an update from laboratory and clinical data. Clin Exp Immunol. 2010 Jun;160(3):295-304.
12 Kim JY, Kwon JH, Ahn SH, Lee SI, Han YS, Choi YO, Lee SY, Ahn KM, Ji GE. Effect of probiotic mix (Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double-blind, randomized, placebo-controlled trial. Pediatr Allergy Immunol. 2010 Mar;21(2 Pt 2):e386-93. e386.
13 Prakash S, Rodes L, Coussa-Charley M, Tomaro-Duchesneau C. Gut microbiota: next frontier in understanding human health and development of biotherapeutics. Biologics. 2011;5:71-86.
14 Williams EA, Stimpson J, Wang D, Plummer S, Garaiova I, Barker ME, Corfe BM. “Clinical trial: a multistrain probiotic preparation significantly reduces the symptoms of irritable bowel syndrome in a double-blind placebo-controlled trial.” Alimentary Pharmacology & Therapeutics. 2008. 29(1):97-103.
15 Plummer, S., Weaver, M.A., Harris, J.C., Dee, P. and Hunter, J. “ Clostridium difficile pilot study: effects of probiotics supplementation on the incidence of C.difficile diarrhea.” International Microbiology. 2004; 7(1):59-62.
16 Williams EA, Stimpson J, Wang D, Plummer S, Garaiova I, Barker ME, Corfe BM. “Clinical trial: a multistrain probiotic preparation significantly reduces the symptoms of irritable bowel syndrome in a double-blind placebo-controlled trial.” Alimentary Pharmacology & Therapeutics. 2008. 29(1):97-103.

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